Pat salmon dry and season with salt and pepper. Whisk honey, soy sauce, rice vinegar, sesame oil, and red pepper flakes in a small bowl. Keep minced garlic separate until cooking.
Heat a skillet over medium-high heat with olive oil. Sear salmon presentation-side down for 3–4 minutes until golden. Flip and cook 2–4 minutes more depending on thickness.
Reduce heat to medium. Push salmon to the side, sauté garlic briefly until fragrant, then pour in the honey-soy mixture. Let it bubble and thicken, basting salmon for 1–2 minutes until glaze becomes glossy.
Turn off heat, spoon extra glaze over fillets, and garnish with green onions and sesame seeds. Serve immediately with lemon wedges.
Notes
Make the glaze up to 3 days ahead and warm gently before using.
For a thicker glaze, whisk 1/2 teaspoon corn starch with 2 teaspoons water and add while simmering.
Leftovers keep in the refrigerator for up to 2 days; reheat gently in a low oven.